The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals.
Abstract
Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuSC function. The combination of the two compounds promoted MuSC function in vivo in aged mice and in primary cells isolated from older individuals. Furthermore, the two compounds were lower in the circulation of older men, paralleling decreases in lean mass and gait speed. These results advance the translational perspective of rejuvenating MuSC function through nutraceuticals.
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Research summary
The paper addresses the rejuvenation of muscle stem cell function, which is directly related to the aging process and muscle regeneration. By identifying nutraceuticals that can enhance MuSC function in aged models, it contributes to understanding potential interventions for age-related decline in muscle regeneration. However, while the findings are solid, they represent an incremental advance rather than a major breakthrough, limiting the overall impact score.
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