Ameliorating Oxidative Stress-Aggravated Adipose Tissue Senescence by Sesamol in Aged Obese Mice via Nrf2/p38MAPK Signaling.

Yongyan Tang, Wenya Zheng, Jingfang Chen, Yan Xie, Jinxin Yang, Zhipeng Wang, Hong Qin

Xiangya School of Public Health, Central South University, Changsha, China.Xiangya School of Public Health, Central South University, Changsha, China. · pubmed

Paper

Abstract

Adipocyte senescence is one of the major common features correlated with aging, which can also lead to obesity, and aggravated oxidative stress contributes to cell senescence. Sesamol, a lignan from plants found in sesame, has been proven to alleviate obesity. However, the effects and mechanisms of sesamol on adipose tissue senescence remain unclear. In the current research, we used an aged model of obesity by feeding old mice high-fat diet (HFD), and a senescent cell model by treating 3T3-L1 mature adipocytes with repeated exposure to hydrogen peroxide (H

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Research summary

The paper investigates the effects of sesamol on adipose tissue senescence, which is a relevant aspect of aging and its associated mechanisms. However, while it addresses oxidative stress and adipocyte senescence, the findings appear to be more incremental rather than groundbreaking. The study contributes to understanding the role of sesamol in obesity and aging but does not present a major breakthrough or transformative implications for longevity research.

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