Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Yang Li, Zhongyuan Liu, Hongyu Yan, Tianle Zhou, Liming Zheng, Feng Wen, Guanghui Guo, Zhiwen Zhang

Department of Orthopedic Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Shizhen Laboratory, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan 430061, China.Department of Orthopedic Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Shizhen Laboratory, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan 430061, China. · pubmed

Paper

Abstract

Sarcopenia is currently a life-threatening disease for the elderly. Polygonatum sibiricum polysaccharide (PSP) has anti-oxidative stress and anti-inflammatory effects. However, the effects of PSP on skeletal muscle aging, myoblast differentiation and mitochondrial dysfunction through PI3K/Akt/mTOR signaling pathway has not been explored.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of Polygonatum sibiricum polysaccharide on skeletal muscle aging and mitochondrial dysfunction, which are directly related to the aging process and sarcopenia, a significant age-related condition. However, while the study addresses an important aspect of aging, it appears to be an incremental advance rather than a groundbreaking discovery, thus limiting its overall impact.

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