The CALERIE Genomic Data Resource.

C P Ryan, D L Corcoran, N Banskota, C Eckstein Indik, A Floratos, R Friedman, M S Kobor, V B Kraus, W E Kraus, J L MacIsaac, M C Orenduff, C F Pieper, J P White, L Ferrucci, S Horvath, K M Huffman, D W Belsky

Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. [email protected] N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. [email protected]. · pubmed

Paper

Abstract

Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 .

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper presents a genomic data resource derived from a randomized controlled trial on caloric restriction, which is directly related to understanding the biological mechanisms of aging and lifespan extension. The datasets generated have the potential to advance translational geroscience, making it a significant contribution to the field. However, while the findings are important, they do not represent a major breakthrough but rather an important step in understanding the effects of caloric restriction on aging.

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