Emerging therapeutic strategies to mitigate female and male reproductive aging.
Abstract
People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development. Preclinical studies, in mouse models of aging, have identified pharmaceutical candidates that improve egg and sperm quality. Further, a diverse array of medically assisted reproduction methodologies, including those that stimulate rare ovarian follicles and rejuvenate egg quality using mitochondria, may have future utility for older patients. Finally, we highlight the many knowledge gaps and possible future directions in the field of therapeutics to extend the age of healthy human reproduction.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper addresses the issue of reproductive aging, which is a significant aspect of longevity research as it pertains to extending healthy reproductive lifespan. However, the findings are primarily based on preclinical studies and highlight knowledge gaps rather than presenting strong clinical evidence or breakthroughs. Thus, while it contributes to the understanding of reproductive aging, its impact is limited and more exploratory in nature.
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