The dominance of old blood, and age-related increase in protein production and noise.

Alexandra Sviercovich, Xiaoyue Mei, Grace Xie, Michael J Conboy, Irina M Conboy

Department of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: [email protected] of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

This concise review provides new perspectives on systemic reduction of tissue aging by comparing different strategies, such as heterochronic parabiosis, injections of young blood plasma, neutral blood exchange (NBE) and therapeutic plasma exchange (TPE). Unlike previous literature that primarily discusses the need for young blood factors, we emphasize the potential of diluting age-elevated proteins as the way to re-calibrate systemic proteome to its younger state without donor blood. Furthermore, we introduce modulation of proteome noise, as an important part of understanding tissue aging and as a critical mechanism for tissue rejuvenation. We discuss studies on the dominance of aged systemic milieu in promoting progeric phenotypes in young cells, in vitro, and in multiple tissues of young animals, in vivo. We support our arguments with evidence showing a significant age-related increase in protein synthesis, in noise of newly synthesized proteomes, and in the rapid induction of these aging phenotypes in young muscle by exposure to aged tissue. We summarize the significance of these findings for future research on aging and longevity.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses systemic reduction of tissue aging and presents new strategies for addressing age-related changes in the proteome, which aligns with the goals of longevity research. It emphasizes the potential for diluting age-elevated proteins and modulating proteome noise as mechanisms for rejuvenation, contributing to the understanding of aging processes. However, while the findings are solid and provide a new perspective, they do not represent a major breakthrough or transformative implications for the field, hence the moderate impact score.

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