Peroxisomes are underappreciated organelles hijacked by viruses.
Abstract
Peroxisomes are cellular organelles that are crucial for metabolism, stress responses, and healthy aging. They have recently come to be considered as important mediators of the immune response during viral infections. Consequently, various viruses target peroxisomes for the purpose of hijacking either their biogenesis or their functions, as a means of replicating efficiently, making this a compelling research area. Despite their known connections with mitochondria, which have been the object of considerable research on account of their role in the innate immune response, less is known about peroxisomes in this context. In this review, we explore the evolving understanding of the role of peroxisomes, highlighting recent findings on how they are exploited by viruses to modulate their replication cycle.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses the role of peroxisomes in metabolism and stress responses, which are relevant to aging and longevity. However, it primarily focuses on how viruses exploit these organelles rather than addressing the root causes of aging or proposing solutions for lifespan extension. The findings may contribute to a better understanding of cellular processes related to aging, but the impact is limited as it does not present significant advancements or breakthroughs in the field of longevity research.
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