Intestinal Microbiota and Aging in People with HIV-What We Know and What We Don't.
Abstract
People with HIV (PWH) experience premature aging and an elevated risk of age-related comorbidities, even with viral suppression through antiretroviral therapy (ART). We examine gastrointestinal disruptions, specifically impaired intestinal barrier integrity and microbial dysbiosis, as contributors to these comorbidities.
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Research summary
The paper addresses the relationship between intestinal microbiota and aging in people with HIV, focusing on gastrointestinal disruptions that contribute to age-related comorbidities. While it touches on aspects of aging and potential contributors to health decline, it primarily discusses the implications of microbial dysbiosis rather than offering insights into root causes of aging or lifespan extension. Thus, it presents solid research but with limited impact on the broader field of longevity.
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