Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells.

Helena Borland Madsen, Claudia Navarro, Emilie Gasparini, Jae-Hyeon Park, Zhiquan Li, Deborah L Croteau, Vilhelm A Bohr

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. · pubmed

Paper

Abstract

During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA and NR are considered safe dietary supplements, it is equally important to understand their function in normal cells and in disease states.

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Research summary

The paper investigates the effects of Urolithin A and Nicotinamide Riboside on microglial cells, which are important in the context of aging and neuroinflammation. While it addresses mechanisms that could be linked to aging processes, the focus on specific cellular responses rather than broader implications for lifespan extension or root causes of aging limits its impact. The findings may contribute to understanding cellular health in aging but do not present a significant breakthrough or transformative insights into longevity research.

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