Metabolic regulation in adult and aging skeletal muscle stem cells.

Vittorio Sartorelli, Veronica Ciuffoli

Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA [email protected] of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA [email protected]. · pubmed

Paper

Abstract

Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In this review, we explore how metabolic pathways, metabolites, and transcriptional and epigenetic regulators are functionally interlinked in adult and aging skeletal muscle stem cells.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses metabolic regulation in adult and aging skeletal muscle stem cells, which is pertinent to understanding the mechanisms of aging and potential interventions to enhance muscle regeneration and function in older adults. While it provides solid insights into the interplay between metabolism and stem cell behavior, the findings appear to be more of an incremental advance rather than a groundbreaking discovery that could significantly alter the field of longevity research.

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