Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain.

Matthew S Stratton, José Alberto López-Domínguez, Alessandro Canella, Jon J Ramsey, Gino A Cortopassi

Department of Physiology & Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, United States. Electronic address: [email protected] of Physiology & Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, United States. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and can shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet (KD) improves cognitive function in aged animals, yet long term adherence to KD in Humans is poor.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of ketogenic diets on gene expression in the aging mouse brain, which is pertinent to understanding potential interventions for aging and neurodegenerative conditions. However, while it contributes to the knowledge of dietary impacts on aging, the findings appear to be incremental rather than groundbreaking, limiting its overall impact on the field of longevity research.

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