Quercetin mitigates iron-induced cell death in chicken granulosa cell.

Shuo Wei, Felix Kwame Amevor, Xiaxia Du, Linxiang Li, Zhixin Yi, Gang Shu, Yan Wang, Xiaoling Zhao

State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China. · pubmed

Paper

Abstract

Granulosa cell (GC) apoptosis, ferroptosis, and other programmed cell death processes are markers of follicular aging. Quercetin has been shown to reduce ferroptosis, however, its effects on ferroptosis in poultry remains unexplored. Our preliminary study identified ferroptosis in aging ovaries. Therefore, in the present study, 540-day-old Mountain Plum-blossom chickens were fed with quercetin supplementation at varying doses (0.2, 0.4, and 0.6 g/kg), and examined its molecular effects on GC ferroptosis using an in vitro Erastin-induced model.

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Research summary

The study investigates the effects of quercetin on ferroptosis in granulosa cells, which is linked to follicular aging in chickens. While it addresses a mechanism related to aging, the focus is on a specific model organism and does not directly tackle broader implications for longevity or lifespan extension in humans. The findings may contribute to understanding cellular processes in aging but are limited in their applicability and significance to the field of longevity research.

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