The impact of creatine levels on musculoskeletal health in the elderly: a mendelian randomization analysis.
Abstract
Musculoskeletal health among the elderly emerges as a pivotal public health concern against the backdrop of a globally aging population. Creatine, popular within fitness circles, has emerged as a subject of scientific inquiry for its potential benefits on elderly' musculoskeletal well-being. Despite extensive documentation of its effects on athletic performance, investigations into creatine's long-term contributions to the musculoskeletal health of the elderly are comparatively limited. Utilizing publicly accessible genetic datasets, this study aimed to explore the potential causal link between creatine levels and a variety of musculoskeletal health markers in the elderly population, such as osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis (OP), bone-specific alkaline phosphatase, bone mineral density(BMD), serum calcium levels, and reduced hand grip strength in individuals aged 60 and above.
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Research summary
The paper investigates the relationship between creatine levels and musculoskeletal health in the elderly, which is pertinent to aging and age-related health issues. However, it primarily focuses on the effects of creatine as a supplement rather than addressing the root causes of aging or longevity. The findings may contribute to understanding musculoskeletal health in older adults, but they do not represent a significant advancement in the field of longevity research. Thus, the impact is rated as a solid but limited contribution.
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