Association of aging acceleration with serum neurofilament light chain levels: Implications for the roles of modifiable aging factors.

Liwei Tang, Min Liu, Yifan Tao, Janice M Ranson, Valerio Napolioni, Haidong Wang, Jie Huang

Department of School of Public Health and Emergency Medicine, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Shenzhen 518055, China.Department of School of Public Health and Emergency Medicine, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Shenzhen 518055, China. · pubmed

Paper

Abstract

Neurofilament light chain (NfL) is a specific biomarker of neuroaxonal damage and related neurodegenerative diseases. Aging acceleration, which reflects the impact of modifiable factors on the aging process, is increasingly recognized for its relevance. While normal aging is known to contribute substantially to neuroaxonal damage and many neurodegenerative diseases, the effects of aging acceleration warrant further investigation. This study aimed to investigate the association and causality between aging acceleration and serum NfL levels.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the association between aging acceleration and serum neurofilament light chain levels, which is relevant to understanding modifiable factors that influence the aging process. However, while it touches on important aspects of neurodegeneration and aging, the findings appear to be more incremental rather than groundbreaking, limiting its overall impact on the field of longevity research.

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