Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth.

Jun Wakabayashi, Takahiro Hamaguchi, Masashi Morifuji, Masashi Nagata

Wellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan.Wellness Science Labs, Meiji Holdings Co., Ltd, 1-29-1 Nanakuni, Hachioji, Tokyo, 192-0919, Japan. · pubmed

Paper

Abstract

Dry mouth results from decreased saliva secretion due to aging or drug side effects. Decreased saliva secretion causes dryness in the oral cavity that makes swallowing difficult and increases the risk of aspiration pneumonia. There are few fundamental treatments for dry mouth. Here we investigated whether treatment of old mice with nicotinamide mononucleotide (NMN) improved factors associated with dry mouth. Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured. The amount of nicotinamide adenine dinucleotide (NAD

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Research summary

The paper investigates the effects of nicotinamide mononucleotide (NMN) on cellular senescence and saliva secretion in aged mice, which relates to the aging process and potential interventions to mitigate age-related decline. However, while it addresses a specific symptom of aging (dry mouth), it does not tackle the root causes of aging or lifespan extension directly. The findings may contribute to understanding NMN's role in aging-related conditions, but the impact is limited as it focuses on a specific treatment rather than broader implications for longevity research.

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