Age-related changes in pupil dynamics and task modulation across the healthy lifespan.

Jeff Huang, Matthew L Smorenburg, Rachel Yep, Heidi C Riek, Olivia G Calancie, Ryan H Kirkpatrick, Donald C Brien, Brian C Coe, Chin-An Wang, Douglas P Munoz

Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. · pubmed

Paper

Abstract

The pupil is modulated by luminance, arousal, bottom-up sensory, and top-down cognitive signals, and has increasingly been used to assess these aspects of brain functioning in health and disease. However, changes in pupil dynamics across the lifespan have not been extensively examined, hindering our ability to fully utilize the pupil in probing these underlying neural processes in development and aging in healthy and clinical cohorts. Here, we examined pupil responses during the interleaved pro-/anti-saccade task (IPAST) in healthy participants across the lifespan (

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Research summary

The paper examines age-related changes in pupil dynamics, which can provide insights into cognitive and neural processes across the lifespan. While it contributes to understanding how aging affects brain function, it does not directly address the root causes of aging or propose methods for lifespan extension. Thus, its impact is solid but limited in the broader context of longevity research.

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