The impact of a polyphenol-rich supplement on epigenetic and cellular markers of immune age: a pilot clinical study.
Abstract
Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading to premature death and disability. Programming of the immune system by diet, lifestyle, and environmental factors occurs across the lifespan and influences both makeup and function of the immune system, including immunometabolism. This programming is believed to act in large part through epigenetic modification. Among dietary components that affect this process, polyphenols may play an outsized role. Polyphenols are a widely distributed group of plant nutrients consumed by humans. Certain foods possess distinctive and relatively higher levels of these compounds. One such food is Tartary buckwheat (
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper investigates the effects of a polyphenol-rich supplement on immune aging, which is a relevant aspect of longevity research. It explores how dietary components can influence immune function and epigenetic modifications associated with aging. However, as a pilot clinical study, it likely presents preliminary findings that may not significantly advance the field or provide transformative insights, thus earning a lower impact score.
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