Gut microbiota metabolism of branched-chain amino acids and their metabolites can improve the physiological function of aging mice.
Abstract
The metabolism of branched-chain amino acids by gut microbiota can improve overall health and may reverse aging. In this study, we investigated Parabacteroides merdae, a gut microbe that is known to catabolise branched-chain amino acids (BCAAs). Three metabolites of BCAAs isovalerate, 2-methylbutyrate, and isobutyrate were used to treat D-gal induced aging mice. The results showed that these treatments could delay aging in mice by providing health benefits in reducing oxidative stress and inflammation, improving muscle capacity, reversing brain acetylcholine levels, and regulating blood glucose. The mechanism was preliminarily explored by combining the gut microbiota metagenome and faecal serum metabolome. Parabacteroides merdae altered the species composition and structure of the gut microbiota in mice. Increasing the abundance of beneficial bacteria, such as Bifidobacterium pseudolongum. Three metabolites affects the gut microbiota and the body's pathways of protein and improves the overall health through a variety of signaling pathways. Overall, regulating the gut microbiota involved in branched-chain amino acid metabolism to bring health benefits may be a new way of reversing aging.
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Research summary
The paper investigates the role of gut microbiota metabolism of branched-chain amino acids in improving physiological functions in aging mice, which aligns with the exploration of mechanisms that could potentially reverse aspects of aging. While the findings are interesting and contribute to the understanding of gut microbiota's influence on health during aging, the impact appears to be limited as it primarily focuses on animal models and does not provide a comprehensive solution to the root causes of aging. Thus, it represents solid research but with limited broader implications for longevity research.
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