Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study.

Win Min Han, Hossain M S Sazzad, Mark Bloch, David A Baker, Norman Roth, Ellen Bowden-Reid, Don E Smith, Jennifer F Hoy, Ian Woolley, Robert Finlayson, David J Templeton, Gail V Matthews, Jane Costello, Mark A Dawson, Sarah-Jane Dawson, Mark N Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J Dharan

Kirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia. Electronic address: [email protected] Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia. Electronic address: [email protected]. · pubmed

Paper

Abstract

While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

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Research summary

The paper investigates the associations between HIV infection, clonal hematopoiesis, and geriatric outcomes, which are relevant to understanding age-related diseases and their underlying mechanisms. However, the findings primarily focus on correlations rather than addressing root causes of aging or proposing interventions for lifespan extension. Thus, while it contributes to the field of aging research, its impact is limited and more incremental than transformative.

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