Effect of thyroid status modulation on pituitary and peripheral hormone concentrations in healthy older subjects.
Abstract
Depending on age, sex, and familial longevity, alterations in thyroid status occur frequently, and often co-occur with differences in other hormonal axes. However, studies that explore the effects of thyroid status modulation on other hormonal axes remain scarce. We aim to determine the effects of thyroid status modulation on prolactin, IGF-1, cortisol, LH, testosterone, and SHBG levels. We also explored whether effects differed depending on type of challenge, sex, and familial longevity.
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Research summary
The paper investigates the modulation of thyroid status and its effects on various hormonal axes in healthy older subjects, which is pertinent to understanding hormonal changes associated with aging. However, while it contributes to the knowledge of hormonal interactions in the context of aging, it does not address root causes of aging or propose mechanisms for lifespan extension. Thus, its impact is solid but limited.
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