Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier.

Francesca Tomatis, Susana Rosa, Susana Simões, Marta Barão, Carlos Jesus, João Novo, Emanuel Barth, Manja Marz, Lino Ferreira

CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Parque Tecnológico de Cantanhede, Coimbra, Portugal.CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Parque Tecnológico de Cantanhede, Coimbra, Portugal. · pubmed

Paper

Abstract

Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesicles (EVs)) that exist in the bloodstream. Therefore, inspiration can be taken from aging to develop new strategies for the transient opening of the BBB for drug delivery to the brain.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the challenge of drug delivery to the brain by focusing on the blood-brain barrier (BBB) and its permeability changes with aging. This is relevant to longevity research as it explores a potential strategy to enhance drug delivery mechanisms that could be beneficial for age-related diseases. However, the approach appears to be more of an incremental advance rather than a groundbreaking discovery, hence the moderate impact score.

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