Antioxidant and antiaging activities of the polysaccharide ZJP-04M from Ziziphus jujuba in Caenorhabditis elegans.

Qing Liu, Yan-Ling Yi, Xiao-Fei Liang, Meng-Ting Wu, Jie Li, Xin Chen, Fang Zhang, Qin-Li Ruan, Feng Liu, Jin-Ao Duan, Sheng Guo

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. · pubmed

Paper

Abstract

Aging is a social problem that people pay particular attention to. Oxidative stress is closely related to aging. Natural polysaccharides have numerous biological activities, and they show good application prospect in preventing oxidative stress and aging prospects. Herein, morphological analysis, molecular weight analysis, monosaccharide composition, methylation analysis, and NMR spectrum analysis were used to characterize the structure of ZJP-04M, an isolated homogeneous polysaccharide from the Ziziphus jujuba fruit. Results indicated that in ZJP-04M, the trunk chain was formed through the alternately connected homogalacturonan skeleton and rhamnogalacturonan-I domain and the branch chain was formed by arabinan and arabinogalactan. After feeding the polysaccharide to Caenorhabditis elegans, ZJP-04M was found to exert a certain paraquet-induced protective effect on the oxidative damage. Under normal conditions, ZJP-04M could significantly prolong the lifespan of C. elegans but exhibited no obvious effect on its reproductive capacity. We futher confirmed that ZJP-04M can play an antiaging role by regulating DAF-16. Based on these results, ZJP-04M can be used in antioxidation and antiaging applications.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of a natural polysaccharide on oxidative stress and lifespan extension in Caenorhabditis elegans, which is directly related to aging and longevity research. However, while the findings are interesting, they represent a solid but incremental advance in the field, lacking groundbreaking implications or novel insights that would significantly alter current understanding or practices in antiaging research.

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