Caloric restriction mimetics: Pinostilbene versus resveratrol regarding SIRT1 and SIRT6 interaction.

Anca Ungurianu, Denisa Margină, Dragoș P Mihai, Alina C Nicolae, Cristina M Drăgoi, Daniela Grădinaru, Anca Zanfirescu

Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. · pubmed

Paper

Abstract

Caloric restriction (CR), the permanent or periodic reduction of caloric intake, is a dietary strategy that promotes longevity and healthspan, yielding multiple beneficial effects, such as improved insulin sensitivity and mitochondrial function, decreased body weight, and mitigation of cardiometabolic risk factors. The purpose of our study was the in silico and in vitro assessment of the effects exerted by pinostilbene on SIRT1 and SIRT6 compared to those of resveratrol, a known activator of these enzymes.

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Research summary

The paper investigates the effects of pinostilbene and resveratrol on SIRT1 and SIRT6, which are enzymes associated with the mechanisms of caloric restriction and longevity. This focus on caloric restriction mimetics and their interaction with longevity-related pathways makes it relevant to aging research. However, the study appears to be more of a comparative analysis rather than presenting groundbreaking findings, thus limiting its overall impact in the field.

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