An integrated single-cell atlas of blood immune cells in aging.
Abstract
Recent advances in single-cell technologies have facilitated studies on age-related alterations in the immune system. However, previous studies have often employed different marker genes to annotate immune cell populations, making it challenging to compare results. In this study, we combined seven single-cell transcriptomic datasets, comprising more than a million cells from one hundred and three donors, to create a unified atlas of human peripheral blood mononuclear cells (PBMC) from both young and old individuals. Using a consistent set of marker genes for immune cell annotation, we standardized the classification of immune cells and assessed their prevalence in both age groups. The integrated dataset revealed several consistent trends related to aging, including a decline in CD8
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Research summary
The paper is relevant to longevity research as it investigates age-related alterations in the immune system, which is a critical aspect of the aging process. By creating a unified atlas of immune cells and identifying trends associated with aging, the study contributes to our understanding of how immune function changes over time, potentially informing strategies to mitigate age-related decline. However, while the findings are solid and provide a useful resource, they do not represent a major breakthrough or transformative advancement in the field, hence the moderate impact score.
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