Gut microbiota and epigenetic age acceleration: a bi-directional Mendelian randomization study.

Han Xu, Ouyang Li, Dayoung Kim, Zhijun Bao, Fan Yang

Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China. · pubmed

Paper

Abstract

The gut microbiota is closely related to aging, but the genetic relationship between gut microbiota and aging has not been well investigated. The aim of the study was to explore the association of microbiota with epigenetic age acceleration (EAA) using the Mendelian randomization.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between gut microbiota and epigenetic age acceleration, which is pertinent to understanding biological aging mechanisms. While it contributes to the field by employing Mendelian randomization to explore genetic links, the findings may be considered solid but not groundbreaking, thus limiting its overall impact.

Author of this paper? Send a correction.