Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.

Haijing Zhao, Nian Cao, Qi Liu, Yingyue Zhang, Rui Jin, Huiying Lai, Li Zheng, Honghong Zhang, Yue Zhu, Yuhan Ma, Zengao Yang, Zhengfeng Wu, Weini Li, Yuqi Liu, Long Cheng, Yundai Chen

Department of Cardiology, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing, 100037, People's Republic of China.Department of Cardiology, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing, 100037, People's Republic of China. · pubmed

Paper

Abstract

Excessive oxidative stress is known to cause endothelial dysfunction and drive cardiovascular diseases (CVD). While telomerase reverse transcriptase (TERT) shows protective effects against oxidative stress in rodents and is associated to human flow-mediated dilation in CVD, its regulatory mechanisms in human vascular systems under pathological oxidative stress require further investigation.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the role of TERT in protecting vascular organoids from oxidative stress, which is relevant to aging and age-related diseases, particularly cardiovascular diseases. However, the findings appear to be more focused on understanding a specific mechanism rather than addressing the root causes of aging or lifespan extension. Thus, while it contributes to the field, its impact is limited and more incremental than transformative.

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