Loss of

Emmanuela Adjei-Sowah, Elsa Lecaj, Neeta Adhikari, Clara Sensini, Anne E C Nichols, Mark R Buckley, Alayna E Loiselle

Department of Biomedical Engineering, University of Rochester; Rochester, NY 14623, USA. · pubmed

Abstract

Aging tendons undergo disruptions in homeostasis, increased susceptibility to injury, and reduced capacity for healing. Exploring the mechanisms behind this disruption in homeostasis is essential for developing therapeutics aimed at maintaining tendon health through the lifespan. We have previously identified that the extracellular matrix protein,

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the mechanisms behind disruptions in tendon homeostasis due to aging, which is relevant to understanding the biological processes of aging and developing therapeutics aimed at maintaining tendon health throughout the lifespan. However, the focus on tendons and their healing capacity suggests a more niche area of research with limited broader implications for longevity science, resulting in a modest impact score.

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