Rab8a restores diverse innate functions in CD11c

Sudhakar Singh, Azeez Tehseen, Surbhi Dahiya, Yuviana J Singh, Roman Sarkar, Sharvan Sehrawat

Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India. · pubmed

Paper

Abstract

Age-related alterations of the immune system compromise the host's ability to respond to pathogens, but how immune aging is regulated is still poorly understood. Here, we identify via transcriptomic analysis of splenic DCs and bone marrow derived dendritic cells (BMDC) of young and aged mice, the small GTPase Rab8a as a regulator of dendritic cell (DC) functions in mice. CD11c

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Research summary

The paper investigates the role of Rab8a in regulating dendritic cell functions, which is pertinent to understanding immune aging and its implications for longevity. However, while it contributes to the knowledge of immune system alterations with age, the findings appear to be incremental rather than groundbreaking, limiting its overall impact on the field of longevity research.

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