Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance.

Gaia Gherardi, Anna Weiser, Flavien Bermont, Eugenia Migliavacca, Benjamin Brinon, Guillaume E Jacot, Aurélie Hermant, Mattia Sturlese, Leonardo Nogara, Filippo Vascon, Agnese De Mario, Andrea Mattarei, Emma Garratt, Mark Burton, Karen Lillycrop, Keith M Godfrey, Laura Cendron, Denis Barron, Stefano Moro, Bert Blaauw, Rosario Rizzuto, Jerome N Feige, Cristina Mammucari, Umberto De Marchi

Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy. · pubmed

Paper

Abstract

Mitochondrial calcium (mtCa

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates mitochondrial calcium uptake and its decline during aging, which is directly related to energy metabolism and skeletal muscle performance. This focus on mitochondrial function and its implications for aging processes makes it relevant to longevity research. However, while the findings may contribute to our understanding of aging mechanisms, they appear to be a solid but incremental advance rather than a groundbreaking discovery, hence the moderate impact score.

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