A brief historic review of research on early life stress and inflammation across the lifespan.
Abstract
Substantial evidence from epidemiological and clinical studies suggests that exposure to stress during sensitive developmental periods strongly and robustly increases the risk for psychiatric and physical disorders, resulting in reduced longevity. Chronic immune activation has been proposed as one mechanism through which early adverse experiences may become biologically embedded. This paper highlights selected key findings and questions that first emerged in the literature and founded the field and then examines how research methods and questions have evolved over time.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses the relationship between early life stress and inflammation, linking these factors to increased risks for various disorders that can affect longevity. While it touches on mechanisms that may contribute to reduced lifespan, it primarily focuses on the historical context and evolution of research rather than presenting novel findings or solutions to the root causes of aging. Thus, it has a solid but limited impact on the field of longevity research.
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