Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans.

Abel Torres-Espin, Hannah L Radabaugh, Scott Treiman, Stephen S Fitzsimons, Danielle Harvey, Austin Chou, Cutter A Lindbergh, Kaitlin B Casaletto, Lauren Goldberger, Adam M Staffaroni, Pauline Maillard, Bruce L Miller, Charles DeCarli, Jason D Hinman, Adam R Ferguson, Joel H Kramer, Fanny M Elahi

School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON N2L 3G1, Canada. · pubmed

Paper

Abstract

Aberrant angiogenesis could contribute to the development of cognitive impairment and represent a therapeutic target for preventing dementia. However, most studies addressing angiogenesis and cognitive impairment focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in a pooled two-center sample from deeply phenotyped longitudinal human cohorts (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the association between angiogenesis markers and brain aging trajectories in humans, which is relevant to understanding mechanisms underlying cognitive aging. However, it primarily focuses on correlational findings rather than addressing root causes of aging or proposing interventions for lifespan extension. The contribution is solid but does not significantly advance the field of longevity research.

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