Pharmacological Activities of

Mohd Wajid Ali Khan, Subuhi Sherwani, Muna H E Alshammari, Abdulmohsen K D Alsukaibi, Wahid Ali Khan, Ashanul Haque, Khalaf M Alenezi, Uzma Shahab

Department of Chemistry, College of Sciences, University of Ha'il, Ha'il 55473, Saudi Arabia.Department of Chemistry, College of Sciences, University of Ha'il, Ha'il 55473, Saudi Arabia. · pubmed

Paper

Abstract

Controlled non-enzymatic glycation reactions are common under normal physiological conditions. However, during elevated blood glucose conditions, the glycation reactions are accelerated, leading to the formation of toxic compounds such as advanced glycation end products (AGEs). Several natural products are now being investigated as protective agents against glycation to preserve blood protein structure and functions.

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Research summary

The paper discusses the role of advanced glycation end products (AGEs) in the context of elevated blood glucose and their toxic effects, which are relevant to aging and age-related diseases. The investigation of natural products as protective agents against glycation could contribute to understanding mechanisms that preserve protein function and potentially mitigate some aspects of aging. However, the focus appears to be more on symptom management rather than addressing root causes of aging, limiting its overall impact.

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