Long Noncoding RNA lncRNA-3 Recruits PRC2 for MyoD1 Silencing to Suppress Muscle Regeneration During Aging.
Abstract
Lowered muscle regenerative capacity in the elderly greatly contributes to the development of multiple diseases. The specific roles of long noncoding RNAs (lncRNAs) in muscle regenerative capacity during aging remain unknown. Here, we identify an elevated lncRNA (lncRNA-3), in association with reduced MyoD expression and suppressed muscle regenerative capacity, in the skeletal muscle of aged mice. LncRNA-3 could interact with both the
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Research summary
The paper investigates the role of long noncoding RNA lncRNA-3 in muscle regeneration during aging, which is directly related to the biological processes of aging and the decline in regenerative capacity. While it provides solid research on a specific mechanism affecting muscle regeneration, its findings are somewhat incremental and may not lead to immediate breakthroughs in longevity research.
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