Potential Vitamin E Signaling Mediators in Skeletal Muscle.
Abstract
Vitamin E (Vit E) deficiency studies underline the relevance of this vitamin in skeletal muscle (SkM) homeostasis. The knowledge of the effectors and modulators of Vit E action in SkM cells is limited, especially in aging and chronic diseases characterized by a decline in musculoskeletal health. Vit E comprises eight fat-soluble compounds grouped into tocopherols and tocotrienols, which share the basic chemical structure but show different biological properties and potentials to prevent diseases. Vit E has antioxidant and non-antioxidant activities and both favorable and adverse effects depending on the specific conditions and tissues. In this review, we focus on the actual knowledge of Vit E forms in SkM functions and new potential signaling effectors (i.e., bioactive sphingolipids and myokines). The possible advantages of Vit E supplementation in counteracting SkM dysfunctions in sarcopenia and under microgravity will also be discussed.
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Research summary
The paper discusses the role of Vitamin E in skeletal muscle health, particularly in the context of aging and conditions like sarcopenia, which are directly related to age-related decline in musculoskeletal function. While it addresses important aspects of muscle homeostasis and potential signaling pathways, the findings appear to be more of a review of existing knowledge rather than presenting novel experimental data or groundbreaking insights. Thus, while it contributes to the understanding of Vitamin E's role in aging, its overall impact on the field is limited.
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