Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer.

Brittany L Angarola, Siddhartha Sharma, Neerja Katiyar, Hyeon Gu Kang, Djamel Nehar-Belaid, SungHee Park, Rachel Gott, Giray N Eryilmaz, Mark A LaBarge, Karolina Palucka, Jeffrey H Chuang, Ron Korstanje, Duygu Ucar, Olga Anczuków

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. · pubmed

Paper

Abstract

Aging is the greatest risk factor for breast cancer; however, how age-related cellular and molecular events impact cancer initiation is unknown. In this study, we investigated how aging rewires transcriptomic and epigenomic programs of mouse mammary glands at single-cell resolution, yielding a comprehensive resource for aging and cancer biology. Aged epithelial cells exhibit epigenetic and transcriptional changes in metabolic, pro-inflammatory and cancer-associated genes. Aged stromal cells downregulate fibroblast marker genes and upregulate markers of senescence and cancer-associated fibroblasts. Among immune cells, distinct T cell subsets (Gzmk

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Research summary

The paper investigates the cellular and molecular changes associated with aging in mammary tissues, which is relevant to understanding the biological mechanisms of aging. However, while it provides insights into the epigenomic and transcriptomic alterations linked to aging and cancer, it does not directly address the root causes of aging or propose interventions for lifespan extension. Thus, it represents solid research but with limited impact on the broader field of longevity research.

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