Fecal microbiota transplantation, a tool to transfer healthy longevity.

Marta G Novelle, Beatriz Naranjo-Martínez, Juan L López-Cánovas, Alberto Díaz-Ruiz

Department of Genetics, Physiology and Microbiology (Unity of Animal Physiology), Faculty of Biology, Complutense University of Madrid (UCM), Madrid, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Spain.Department of Genetics, Physiology and Microbiology (Unity of Animal Physiology), Faculty of Biology, Complutense University of Madrid (UCM), Madrid, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Spain. · pubmed

Paper

Abstract

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the role of the gut microbiome in aging and the potential of Fecal Microbiota Transplantation (FMT) to promote healthy aging, which aligns with longevity research. However, while it reviews existing studies and explores the concept of microbial rejuvenation, it does not present new experimental data or significant findings that would advance the field substantially. The challenges mentioned regarding FMT also indicate that the application of this research is still in its early stages, limiting its immediate impact.

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