Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins.

Qihua Tan, Hikmat Alo, Marianne Nygaard, Mette Sørensen, Alisa Saleh, Jonas Mengel-From, Kaare Christensen

Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark. · pubmed

Paper

Abstract

We aimed to explore the age-dependent epigenetic variability on the X-chromosome with consideration of X-chromosome inactivation by applying a sex-stratified regression analysis to DNA methylation array data on X-linked CpGs in aging identical twins. We found 13 X-linked CpGs showing age-related significant increase in variability in males (FDR < 0.05) but none in females. In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates age-dependent DNA methylation variability on the X-chromosome, which is relevant to understanding epigenetic changes associated with aging. However, the findings are limited to variability in males and do not address broader mechanisms of aging or potential interventions. The research contributes to the field of epigenetics in aging but does not present significant advancements that could lead to breakthroughs in longevity or lifespan extension.

Author of this paper? Send a correction.