Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings.

Ana Clara da C Pinaffi-Langley, Camila B Pinto, Peter Mukli, Anna Peterfi, Zalan Kaposzta, Cameron D Owens, Zsofia Szarvas, Mihaly Muranyi, Cheryl Adams, Ali Shahriari, Priya Balasubramanian, Zoltan Ungvari, Anna Csiszar, Shannon Conley, Norman G Hord, Leah Anderson, Stefano Tarantini, Andriy Yabluchanskiy

Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK 73104, USA.Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK 73104, USA. · pubmed

Paper

Abstract

Dysregulated energy metabolism is a hallmark of aging, including brain aging; thus, strategies to restore normal metabolic regulation are at the forefront of aging research. Intermittent fasting, particularly time-restricted eating (TRE), is one of these strategies. Despite its well-established effectiveness in improving metabolic outcomes in older adults, the effect of TRE on preserving or improving cerebrovascular health during aging remains underexplored. We explored how aging itself affects energy metabolism and contextualized these age-related changes to cerebrovascular health. We also conducted a literature search on PubMed and Scopus to identify and summarize current studies on TRE in older adults. Finally, we provided preliminary data from our proof-of-concept pilot trial on the effect of 6-month TRE on cerebrovascular health in older adults. Current evidence shows the potential of TRE to improve energy metabolism and physiological outcomes in older adults. TRE may improve cerebrovascular function indirectly due to its effect on glucose homeostasis. However, to date, direct evidence of the effect of TRE on cerebrovascular parameters is lacking. TRE is a well-tolerated and promising dietary intervention for promoting and maintaining cerebrovascular health in older adults. Further studies on TRE in older adults must be better controlled for energy balance to elucidate its independent effects from those of caloric restriction.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the relationship between energy metabolism dysregulation and cerebrovascular aging, focusing on time-restricted eating (TRE) as a potential intervention. While it explores a dietary strategy that may influence aging-related processes, the findings are preliminary and lack direct evidence linking TRE to cerebrovascular health. The research contributes to the understanding of metabolic regulation in aging but does not provide significant new insights or breakthroughs that would substantially advance the field of longevity research.

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