Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort.

Micah J Savin, Haoyang Wang, Heming Pei, Allison E Aiello, Stephanie Assuras, Avshalom Caspi, Terrie E Moffitt, Peter A Muenning, Calen P Ryan, Baoyi Shi, Yaakov Stern, Karen Sugden, Linda Valeri, Daniel W Belsky

Robert N. Butler Columbia Aging Center Mailman School of Public Health Columbia University Irving Medical Center New York New York USA. · pubmed

Paper

Abstract

The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the association between an epigenetic clock and cognitive decline, which aligns with the geroscience hypothesis that systemic biological aging contributes to age-related cognitive decline. While it provides solid research on the relationship between aging markers and cognitive function, the findings are incremental and do not propose a direct intervention or solution to aging itself, limiting its overall impact on the field of longevity research.

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