Zuogui pills ameliorate chemotherapy-induced ovarian aging by improving stemness, regulating cell cycle and reducing apoptosis of oogonial stem cells via the Notch1/Nrf2 pathway.

Zuang Li, Yuewei Lin, Yuxin Zou, Yunyi Liang, Lihua Zeng, Yixuan Wang, Yucheng Li, Yun Zong, Yuying Zhang, Yunling Zheng, Yixuan Cui, Liuqian Huang, Zhuoting Chen, Xinyi Pan, Ling Zhu

Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address: [email protected] University of Chinese Medicine, Guangzhou, 510006, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Zuogui Pills (ZGP) is a classic traditional Chinese herbal formula originating from the Ming Dynasty. It has been widely used in the treatment of kidney deficiency-related diseases, including ovarian aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of Zuogui Pills on chemotherapy-induced ovarian aging, focusing on mechanisms such as stemness, cell cycle regulation, and apoptosis reduction in oogonial stem cells. While it addresses a specific aspect of aging related to ovarian function, it does not tackle the broader root causes of aging or lifespan extension. The findings may contribute to understanding age-related changes in reproductive health but are limited in their implications for general longevity research. Thus, it represents a solid contribution but with limited impact on the field of aging.

Author of this paper? Send a correction.