Caenorhabditis elegans as a model host to study effects of lactic acid bacteria and functional food factors.
Abstract
Several approaches for regulating health and disease by intestinal bacteria, bacteria isolated from food products, and food factors have been investigated; however, the molecular mechanisms underlying the interactions between these bacteria and their hosts are still unknown. Caenorhabditis elegans is a crucial model for exploring various biological phenomena and has been used in studying intestinal bacteria, mainly in the field of antiaging, anti-amyloid β activity in Alzheimer's disease, and its interaction to hosts. The nematode model is expected to be increasingly utilized for elucidating the interactions of beneficial bacteria or food factors with hosts. Herein, we review anti-aging and suppression of amyloid-β expression in a C. elegans model fed lactic acid bacteria, and our developed methods for orally administering food factors and assessing advanced glycation end products as an aging indicator.
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Research summary
The paper discusses the use of Caenorhabditis elegans to study the effects of lactic acid bacteria and food factors on aging-related processes, specifically focusing on anti-aging mechanisms and amyloid-β expression. While it touches on important aspects of aging research, the findings appear to be incremental and primarily focused on interactions rather than addressing root causes of aging or lifespan extension. Thus, while it is relevant to longevity research, its impact is limited.
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