Increase in PUFA and protein, and decrease in carbohydrate intake improves liver fat in 12 months and the role of weight loss as a mediator: A randomized controlled trial.

Laura Pletsch-Borba, Charlotte Wernicke, Jürgen Machann, Nina Mt Meyer, Thu Huong Nguyen, Anne Pohrt, Silke Hornemann, Christiana Gerbracht, Andreas Fh Pfeiffer, Joachim Spranger, Knut Mai

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, 10117, Berlin, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany.Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, 10117, Berlin, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany. · pubmed

Paper

Abstract

Recently, a beneficial effect of high intake of unsaturated fatty acids (UFA) and protein on intrahepatic lipids (IHL) was demonstrated over 12 months within a randomized controlled trial (the NutriAct trial). We now aimed to explore the specific macronutrient components driving this IHL improvement within this trial in middle-aged and elderly subjects (50-80 y) at risk for age-related diseases.

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Research summary

The paper investigates the effects of specific macronutrient intake on intrahepatic lipids in middle-aged and elderly subjects, which is relevant to age-related metabolic health. However, it primarily focuses on dietary interventions rather than addressing the root causes of aging or lifespan extension. The findings may contribute to understanding dietary impacts on health in older adults, but the overall impact on the field of longevity research is limited.

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