DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.

Denis Firsanov, Max Zacher, Xiao Tian, Todd L Sformo, Yang Zhao, Greg Tombline, J Yuyang Lu, Zhizhong Zheng, Luigi Perelli, Enrico Gurreri, Li Zhang, Jing Guo, Anatoly Korotkov, Valentin Volobaev, Seyed Ali Biashad, Zhihui Zhang, Johanna Heid, Alex Maslov, Shixiang Sun, Zhuoer Wu, Jonathan Gigas, Eric Hillpot, John Martinez, Minseon Lee, Alyssa Williams, Abbey Gilman, Nicholas Hamilton, Ena Haseljic, Avnee Patel, Maggie Straight, Nalani Miller, Julia Ablaeva, Lok Ming Tam, Chloé Couderc, Michael Hoopman, Robert Moritz, Shingo Fujii, Dan J Hayman, Hongrui Liu, Yuxuan Cai, Anthony K L Leung, Mirre J P Simons, Zhengdong Zhang, C Bradley Nelson, Lisa M Abegglen, Joshua D Schiffman, Vadim N Gladyshev, Mauro Modesti, Giannicola Genovese, Jan Vijg, Andrei Seluanov, Vera Gorbunova

Department of Biology, University of Rochester, Rochester, NY, USA. · pubmed

Paper

Abstract

At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates DNA repair and anti-cancer mechanisms in the bowhead whale, which is notable for its exceptional longevity. By exploring the biological processes that contribute to the whale's lifespan, the research has the potential to provide insights into the mechanisms of aging and longevity. However, while the findings may be solid, they are likely to have limited immediate impact on the broader field of longevity research, as they may not directly translate into actionable strategies for lifespan extension in other species.

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