Anthocyanins as potent inhibitors of pentosidine synthesis: Antioxidant-mediated effects.

Mai Asakura, Kazuya Toriumi, Aya Nozaki, Jinwei Yang, Jin Tatsuzaki, Kazuhiro Suzuki, Mitsuhiro Miyashita, Masanari Itokawa, Makoto Arai

Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan; Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. · pubmed

Paper

Abstract

Pentosidine (PEN), an advanced glycation end product (AGE), is associated with various age-related diseases and schizophrenia. This study aimed to identify the natural compounds that inhibit PEN synthesis from glucuronic acid using an in vitro system. A screening of 93 natural compounds revealed 47 that reduced PEN synthesis by > 50 %, with eight inhibiting it by > 80 %. The top five inhibitors were anthocyanins, with petunidin chloride showing the strongest effect, inhibiting PEN synthesis by approximately 90 %. These compounds directly inhibited PEN synthesis without degrading or capturing the synthesized PEN. Petunidin chloride had an IC

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Research summary

The paper investigates the inhibition of pentosidine synthesis, which is associated with age-related diseases. While it identifies natural compounds that may have a role in mitigating a specific advanced glycation end product linked to aging, it does not address the root causes of aging or propose a mechanism for lifespan extension. The findings are interesting but represent a relatively minor contribution to the broader field of longevity research.

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