Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice.

Helene Michenthaler, Kalina Duszka, Isabel Reinisch, Markus Galhuber, Elisabeth Moyschewitz, Sarah Stryeck, Tobias Madl, Andreas Prokesch, Jelena Krstic

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre, Medical University of Graz, Graz, Austria.Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre, Medical University of Graz, Graz, Austria. · pubmed

Paper

Abstract

Dietary restriction (DR) has multiple beneficial effects on health and longevity and can also improve the efficacy of certain therapies. Diets used to instigate DR are diverse and the corresponding response is not uniformly measured. We compared the systemic and liver-specific transcriptional response to intermittent fasting (IF) and commercially available fasting-mimicking diet (FMD) after short- and long-term use in C57BL/6 J mice.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of dietary restriction methods, specifically intermittent fasting and fasting-mimicking diets, on systemic and transcriptional responses in mice. This aligns with longevity research as it explores dietary interventions that may influence health and lifespan. However, while the findings may contribute to understanding dietary impacts on aging, the study appears to provide solid but limited insights without groundbreaking implications for the field.

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