Genetic variants associated with longevity in long-living Indians.

Sandhya Kiran Pemmasani, Shakthiraju R G, Suraj V, Raunaq Bhattacharyya, Chetan Patel, Anil Kumar Gupta, Anuradha Acharya

Mapmygenome India Limited, Hyderabad, India. [email protected] India Limited, Hyderabad, India. [email protected]. · pubmed

Paper

Abstract

Genetic factors play a significant role in determining an individual's longevity. The present study was aimed at identifying genetic variants associated with longevity in Indian population. Long living individuals (LLIs), aged 85+, were compared with younger controls, aged 18-49 years, using data from GenomegaDB, a genetic database of Indians living in India. An in-house developed custom chip, having variants associated with various cancers, cardiovascular, neurological, gastro-intestinal, metabolic and auto-immune disorders, was used to generate genotype data. Logistic regression analysis with sex and top three genetic principal components as covariates resulted in 9 variants to be significantly associated with longevity at a p-value threshold of 5 × 10

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Research summary

The paper investigates genetic variants associated with longevity in a specific population, which is relevant to the field of longevity research. However, the findings appear to be incremental and focused on identifying associations rather than addressing the underlying mechanisms of aging or longevity. The study's impact is limited due to its population-specific nature and the reliance on existing genetic data without exploring broader implications or interventions.

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