Nuezhenide of the fruits of Nuzhenzi (Ligustrum lucidum Ait.) is a functional analog of ghrelin.
Abstract
The dried fruit of Ligustrum lucidum Ait. (FLL), known as Nuzhenzi, is traditionally recognized for its anti-aging properties in Chinese medicine. Nuezhenide, a water-soluble secoiridoid present in FLL, has demonstrated various pharmacological activities including neuroprotection, enhancement of learning and memory, antiosteoporotic, and antiviral activities. These therapeutic benefits align with the anti-aging effects attributed to ghrelin, particularly in the modulation of growth hormone secretagogue receptor type 1a (GHSR-1a) signaling.
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Research summary
The paper discusses Nuezhenide from Ligustrum lucidum Ait. and its potential anti-aging properties, particularly in relation to ghrelin and its signaling pathways. While it touches on aspects of aging and presents some pharmacological activities that may contribute to longevity, the findings appear to be more incremental rather than groundbreaking. The research aligns with traditional uses in Chinese medicine but lacks robust evidence that directly addresses the root causes of aging or significantly advances the field of longevity research.
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