Liquid-liquid phase separation in aging: Novel insights in the pathogenesis and therapeutics.
Abstract
The intricate organization of distinct cellular compartments is paramount for the maintenance of normal biological functions and the orchestration of complex biochemical reactions. These compartments, whether membrane-bound organelles or membraneless structures like Cajal bodies and RNA transport granules, play crucial roles in cellular function. Liquid-liquid phase separation (LLPS) serves as a reversible process that elucidates the genesis of membranelles structures through the self-assembly of biomolecules. LLPS has been implicated in a myriad of physiological and pathological processes, encompassing immune response and tumor genesis. But the association between LLPS and aging has not been clearly clarified. A recent advancement in the realm of aging research involves the introduction of a new edition outlining the twelve hallmarks of aging, categorized into three distinct groups. By delving into the role and mechanism of LLPS in the formation of membraneless structures at a molecular level, this review encapsulates an exploration of the interaction between LLPS and these aging hallmarks, aiming to offer novel perspectives of the intricate mechanisms underlying the aging process and deeper insights into aging therapeutics.
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Research summary
The paper discusses liquid-liquid phase separation (LLPS) in the context of aging, exploring its role in the formation of membraneless structures and its potential implications for the hallmarks of aging. This focus on the mechanisms underlying aging processes provides a relevant perspective for longevity research. However, while the insights may contribute to understanding aging, the paper appears to offer solid research without groundbreaking findings, thus limiting its overall impact.
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