Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study.

Jennifer L Arzu, Karl T Kelsey, George D Papandonatos, Kim M Cecil, Aimin Chen, Scott M Langevin, Bruce P Lanphear, Kimberly Yolton, Jessie P Buckley, Joseph M Braun

Department of Epidemiology, School of Public Health, Brown University, 121 South Main Street, Providence, RI, 02903, USA. [email protected] of Epidemiology, School of Public Health, Brown University, 121 South Main Street, Providence, RI, 02903, USA. [email protected]. · pubmed

Paper

Abstract

Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association with other cardiometabolic risk markers remains understudied. We employed data from the Health Outcomes and Measures of the Environment (HOME) study, a prospective pregnancy and birth cohort in the greater Cincinnati metropolitan area, to examine whether accelerated epigenetic age at birth as well as accelerated epigenetic age and faster pace of biological aging at age 12 years were associated with higher cardiometabolic risk in adolescents.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the association between epigenetic age acceleration and cardiometabolic risk factors in adolescents, which touches on aspects of biological aging. However, it primarily focuses on risk markers rather than addressing the root causes of aging or proposing interventions for lifespan extension. While the findings may contribute to understanding aging-related health issues, they do not significantly advance the field of longevity research.

Author of this paper? Send a correction.