Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation.

Honghan Li, Deqing Luo, Wei Xie, Wenbin Ye, Jinlong Chen, Paolo Alberton, Mingzhu Zhang, Eryou Feng, Denitsa Docheva, Dasheng Lin

Department of Orthopaedic Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, P.R. China.Department of Orthopaedic Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, P.R. China. · pubmed

Paper

Abstract

Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can inhibit bone mass loss and bone microarchitecture alteration in senile osteoporosis mouse model. In addition, irisin has effects on bone remodeling that is in favor of bone formation. Remarkably, irisin induced autophagy in osteocytes demonstrated by increased LC3-positive osteocytes, and increased autophagy-related genes and proteins.

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Research summary

The paper investigates the role of irisin in mitigating senile osteoporosis, which is an age-related condition. While it addresses a mechanism related to bone health in aging, it does not tackle the root causes of aging or lifespan extension directly. The findings contribute to understanding bone metabolism but represent a solid yet limited advance in the field of longevity research.

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